Aprezo 30mg (Apremilast)

Apremilast: Uses, Benefits, Dosage, and Safety Overview

Apremilast is an oral medication used to treat inflammatory autoimmune conditions, most commonly psoriasis and psoriatic arthritis. It belongs to a class of drugs known as phosphodiesterase 4 (PDE4) inhibitors, which work by reducing the production of inflammatory cytokines involved in chronic skin and joint disease. Because it targets inflammation through a non-immunosuppressive pathway, Apremilast has become an important option for patients seeking an alternative to traditional systemic therapies.

Indications

Apremilast is prescribed for:

• Moderate to severe plaque psoriasis, especially in adults who have not responded to or cannot use phototherapy or systemic drugs.

• Active psoriatic arthritis, helping reduce joint swelling, tenderness, and stiffness.

• Oral ulcers in Behçet’s disease, where it helps reduce frequency and severity.

Dosage (General Information)

Apremilast is taken orally, usually twice daily. To reduce gastrointestinal side effects, treatment typically begins with a 5-day dose-titration schedule, gradually increasing to the recommended maintenance dose. The most common final dose is 30 mg twice daily, but adjustments may be required for individuals with kidney impairment. Tablets should be swallowed whole, with or without food, and dosing must follow medical guidance.

How It Works

By inhibiting PDE4, Apremilast increases intracellular cAMP levels, which leads to a reduction in inflammatory mediators such as TNF-α, IL-17, and IL-23. This results in improvement of skin plaques, reduced joint inflammation, and decreased discomfort in chronic autoimmune conditions.

Side Effects & Precautions

Common side effects include diarrhea, nausea, headache, and weight loss. Some individuals may experience mood changes, including depression, which should be reported immediately. Regular monitoring of weight and overall mood is recommended. Apremilast does not require routine laboratory monitoring, making it convenient for long-term therapy.

Conclusion

Apremilast offers an effective, well-tolerated oral option for managing several inflammatory conditions. Its targeted action, combined with minimal lab requirements, makes it an increasingly popular choice for patients and clinicians.