Covifor (Remdesivir Injection)
Active ingredient: Remdesivir
Manufacturer : Hetero Healthcare
Product Code: Rendesivir-3
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What Is Covifor (Remdesivir) ?
Remdesivir (Covifor), an antiviral drug, is used to treat coronavirus disease 2019 (COVID-19) infection caused by the SARS-CoV-2 virus. This infection spreads through contact with infected people. In some individuals, the infection may not show any symptoms; however, in others, symptoms like fever, cough, and breathlessness may appear after 2-14 days of exposure to the virus. 
Remdesivir is being used to treat individuals admitted to the hospital for severe COVID-19 infection. Although research is still being conducted, the FDA has approved this drug for emergency purposes only. It is available in powder form, which is then mixed with a liquid (admixture) and injected through a vein, i.e., intravenously (IV).
Classification and Mechanism of Action
Remdesivir is an inactive (prodrug) form of adenosine triphosphate (ATP) analog.
After administration, this medicine is converted to its active form in the body, which resembles one of the components (ATP) needed for the virus to multiply. This inhibits the replication of the virus, thus preventing the spread of the virus inside the body.[1,3]
Looking After Remdesivir (Covifor)
Ideally, the admixture should be administered immediately after mixing. However, remdesivir admixture can be stored for four hours at room temperature, i.e., 20°C to 25°C (68°F to 77°F) or 24 hours in refrigerated condition, i.e., 2°C to 8°C (36°F to 46°F).
How to Take Covifor
This medicine is usually given intravenously.
This medicine is administered through an IV line for 30 minutes to 120 minutes. The dose for remdesivir varies in adults and children.
In adults, a single dose of 200 mg is given on the first day. They may be given 100 mg from the second day onwards.
If a person requires the assistance of a ventilator, treatment may last for up to 10 days. If no ventilation is needed, the treatment is continued for five days. The treatment may extend for more than five days if no improvement is observed.
If a child weighs between 3.5 kg to less than 40 kg, he/she must receive 5 mg/kg on the first day and 2.5 mg/kg from the second day onwards.
For children with body weight more than 40 kg, the adult dose is administered (200 mg on day one and 100 mg from day two).
As there is no antidote available for this medicine yet, treatment will include checking the vital signs and monitoring the individual. No instances of remdesivir overdose have been reported yet.
Warnings and Precautions
You should let your doctor know if you are allergic to remdesivir or any ingredients in the preparation; are taking any supplements or medicines such as chloroquine or hydroxychloroquine; have liver or kidney disease; or are breastfeeding, pregnant or planning for a pregnancy.
Covifor Possible Side Effects
The side effects of this medicine are not entirely known. You may experience the following symptoms after taking the medicine:
Changes in heartbeat
Wheezing (whistling sound when breathing)
Low blood pressure
Swelling of the lips, throat or face
Nausea or vomiting
Shortness of breath
Swelling or damage to the liver due to increase in liver enzymes
The injection site for the IV line can show the following side effects:
Bruising of the skin
It has been proved that remdesivir has antiviral activity against a variety of viral infections, including coronavirus infections like severe acute respiratory syndrome and Middle East respiratory syndrome. Therefore, it was studied as a therapeutic agent for COVID-19. A clinical trial was performed by Beigel et al. to study the activity of remdesivir against COVID-19. Some participants received remdesivir, whereas some were administered a placebo. Participants who were given remdesivir recovered in 11 days, while those given the placebo took 15 days to recover from the COVID-19 infection.