Coronavirus Treatment

Coronavirus Treatment

Also known as: Generic Kaletra
Active ingredient: Lopinavir + Ritonavir
Product Code: PG907383
Availability:
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Lopinavir/Ritonavir 200/50 mg

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60 tablets
$130.00 USD
$2.17 USD
$0.00 USD
120 tablets
$250.00 USD
$2.08 USD
$10.00 USD
180 tablets
$350.00 USD
$1.94 USD
$40.00 USD

CoronaVirus pack (Ritonavir 50mg + Lopinavir 200mg, Ribavirin 200mg, Oseltamivir 75mg)

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210 pills - Ritonavir + Lopinavir 60 pills, Ribavirin 120 pills, Oseltamivir 30 pills
$400.00 USD
$1.90 USD
$35.56 USD
240 pills - Ritonavir + Lopinavir 60 pills, Ribavirin 120 pills, Oseltamivir 60 pills
$490.00 USD
$2.04 USD
$7.78 USD
270 pills - Ritonavir + Lopinavir 60 pills, Ribavirin 120 pills, Oseltamivir 90 pills
$560.00 USD
$2.07 USD
$0.00 USD

Description

Lopinavir  200 mg + Ritonavir 50 mg Hivus-LR (Generic Kaletra) is manufactured by Aurobindo Pharma Ltd and is indicated for ; AIDS/HIV Treatment.

Hivus-LR (Lopinavir  200 mg + Ritonavir 50 mg) together with 
Ribavirin 200 mg and Antiflu 75 mg (Oseltamivir)
can help fighting with 
Coronavirus (Covid-19).

 

Generic Kaletra - HIVUS-LR 200/50 MG (LOPINAVIR + RITONAVIR)

What Is Generic Kaletra?

Hivus-LR is used in combination with other drugs to treat infection with human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS).[1,2]

Our body contains infection-fighting T (CD4) cells that are a part of the immune system. The HIV virus attacks and destroys these cells, thereby weakening the immune system. In the absence of the immune cells, the body becomes susceptible to a number of infections and certain cancers.[2] Untreated HIV infection leads to AIDS, which is the last stage of infection.[2,3]    

Please note that Hivus-LR neither cures HIV infection nor reduces the risk of passing HIV through sexual contact, but they lower the chance of developing AIDS.[1,4] HIVUS-LR is a combination drug containing two active ingredients: lopinavir and ritonavir.

Classification and Mechanism of Action

Lopinavir and ritonavir are antiviral drugs under the class of protease inhibitors.[4]

The HIV virus contains an enzyme (a protein) called protease. This enzyme is necessary for the breakdown of a substance called gag-pol polyprotein required for the maturity of the virus.[5] Lopinavir and ritonavir inhibit the working of the protease enzyme. The leads to the formation of immature and non-infectious viruses.[5,6]

Looking After Your Drug

Consider the following points for storage of HIVUS-LR (Generic Kaletra):[4]

  • Keep the medicine in the original container in which you received it. If kept out of the container, use the medicine within 2 weeks.
  • Store it at room temperature and away from moisture.
  • Keep the medicine in a safe location – away from the reach of children.

Dosage Form and Strength

Hivus-LR is available in the form of tablets for oral use in the strength of 200 milligrams (mg) lopinavir and 50 mg ritonavir.

Dosage

The recommended dose of Hivus-LR are:

  1. For adults and pediatrics above 12 years of age:[1]
  • Who have never undergone treatment for HIV
  • Two tablets twice a day or 
  • Four tablets once a day
  • Who have previously undergone treatment for HIV
  • Two tablets twice a day (even when taken with other drugs for HIV)

Your doctor may increase your dose to three tablets twice a day when used in combination with other drugs for HIV, after studying your past treatment and laboratory results.[1]

  1. For pediatrics from 6 months to 12 years of age with bodyweight more than 40 kg
  • Two tablets twice a day.[1]

How to Take the Medication?

Hivus-LR tablets are for oral use only. The tablets must be swallowed whole, with or after meals. The tablets should not be crushed or split.[7]

Overdose

Contact the emergency services in case of an overdose. After an overdose, the person may:[4]

  • Collapse
  • Have difficulty breathing
  • Have a seizure
  • Not awake

Warning and Precautions

Take the following precautions before taking Hivus-LR:

  1. Inform your doctor know if you are allergic to any of the ingredient present in the medicine[4]
  2. Inform your doctor if you:[1]
  • Are pregnant or planning to become pregnant
  • Are breastfeeding
  • Have liver problems
  • Have increased bleeding
  • Have diabetes
  1. The following drugs are contraindicated with Hivus-LR:[1]
  • Alfuzosin
  • Astemizole
  • Cisapride
  • Dihydroergotamine
  • Ergotamine
  • Ergonovine
  • Lovastatin
  • Methylergonovine
  • Midazolam
  • Pimozide
  • Rifampin
  • Sildenafil
  • Simvastatin
  • St. John’s wort
  • Terfenadine
  • Triazolam
  1. Share with your doctor the list of all the medicines (prescription and over-the-counter), supplements, and vitamins you are taking.[4]
  2. The efficacy of hormonal contraceptives, such as rings, patches, injections, or birth control pills, decreases with this medicine. Talk to your doctor about alternatives for birth control.[4]
  3. Tell your doctor if you ever had:[4]
  • Irregular heartbeat
  • Low potassium level in the blood
  • High cholesterol in the blood
  • Swelling of the pancreas
  • Heart disease
  • Liver disease

This medicine may increase your blood sugar level even if you are not diabetic. Tell your doctor if you experience symptoms like extreme thirst and hunger, frequent urination, weakness, and blurred vision. 

If you miss a dose, take it as soon as possible. If it is almost time for your next dose, avoid taking a double dose. Instead, ignore the missed dose and carry on with your normal dosing schedule.[4]

Possible Side Effects

Inform your healthcare provider if you observe any of the side-effects mentioned below:

  • Abdominal pain
  • Diarrhea
  • Fatigue
  • Abnormal bowel movements
  • Nausea
  • Headache
  • Loss of fat from face, arms, and legs
  • A build-up of fat in the breast, upper back, neck, and around the trunk

When Should the Drug Not Be Used?

Discuss with your doctor if you are the right candidate to take this drug. Most importantly, other medicines, if taken with HIVUS-LR, could result in side effects that can be fatal.[1] Please speak with your doctor about those medications.

References:

  1. U.S. Food and Drug Administration. Kaletra® [Internet]. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021906s008,021251s019lbl.pdf. Accessed on Feb 14, 2020.
  2. AIDS.info. HIV/AIDS: The basics [Internet]. [Updated Jul 3, 2019]. Available at: https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/19/45/hiv-aids--the-basics. Accessed on Feb 14, 2020.
  3. AIDS.info. HIV and AIDS: What’s the difference? [Internet] [Updated Feb 13, 2019]. Available at: https://aidsinfo.nih.gov/understanding-hiv-aids/infographics/3/hiv-and-aids--what%E2%80%99s-the-difference-. Accessed on Feb 14, 2020.
  4. MedlinePlus. Lopinavir and ritonavir [Internet] [Updated Nov 15, 2016]. Available at: https://medlineplus.gov/druginfo/meds/a602015.html. Accessed on Feb 14, 2020.
  5. DrugBank. Lopinavir [Internet] [Updated Feb 12, 2020]. Available at: https://www.drugbank.ca/drugs/DB01601. Accessed on Feb 14, 2020.
  6. DrugBank. Ritonavir [Internet] [Updated Feb 13, 2020]. Available at: https://www.drugbank.ca/drugs/DB00503. Accessed on Feb 14, 2020.
  7. AIDSinfo. Protease inhibitors [Internet] [Updated Apr 16, 2019]. Available at: https://aidsinfo.nih.gov/guidelines/html/2/pediatric-arv/132/lopinavir-ritonavir. Accessed on Feb 14, 2020.
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