Antiflu 75 mg (Oseltamivir)
Manufacturer : Cipla
Product Code: Coronavirus003
Antiflu 75 mg (Oseltamivir) is used to treat symptoms caused by the flu virus (influenza).
For CoronaVirus (COVID-19) a combination treatment of Antiflu 75 mg (Oseltamivir) together with
ANTIFLU 75MG (OSELTAMIVIR)
What Is This Drug?
Antiflu 75mg is an anti-viral prescription medicine for the management and prevention of influenza A (including H1N1) and influenza B. Its primary ingredient is oseltamivir phosphate, which restricts the activity of viral neuraminidase (explained later).
The U.S. Food and Drug Administration (FDA) advocates the oral administration of oseltamivir for treating influenza in adults and children who are two weeks or older. Oseltamivir is used to prevent influenza in one-year-old children or older.
The medication exhibits maximum benefits when it is taken within 48 hours of manifestation of flu symptoms because its anti-viral effect starts to vanish after 48 hours of appearance of flu symptoms.
Classification and Mechanism of Action
Oseltamivir is one of the anti-viral drugs that belong to the class of neuraminidase inhibitors. It obstructs the working of viral neuraminidase enzymes, which are found on the surface of the virus.
The neuraminidase enzymes have three crucial functions:
- To facilitate the entry of the virus into the uninfected human (host) cells
- To release newly formed virus particles from infected host cells
- To promote the further spread of the infectious virus in the body
Oseltamivir phosphate, an inactive compound, is converted into oseltamivir carboxylate, an active compound, inside the body. The active form restricts the activity of viral neuraminidase enzyme and prevents the release of influenza virus from infected human cells, thereby preventing its spread to other uninfected cells of the body.
Looking After Your Drug
The storage temperature of this medication should be 20–25oC. This medication should be kept away from children’s reach, moisture, and excess heat.[4,5]
Dosage Form and Strength
Antiflu 75mg, which contains 75mg oseltamivir, is available in the form of a capsule for oral administration.
The dosage of this medication varies in adults and children:
- Adults (13 years and older):
- For treatment: Twice regularly for 5 days
- For prevention: Once regularly for 10 days
- In case of a community outbreak: Once regularly for 6 weeks
- For the management of patients with renal impairment who are having creatinine clearance of 10–30 mL/min: Once regularly for 5 days
- Children (1–12 years old with a body weight of 40.1 kg or more):
- For treatment: Twice daily for 5 days
- For prevention: Once daily for 10 days.
How to Take the Medication?
Antiflu 75mg should be administered preferably with food since it decreases the risk of stomach upset. Moreover, it should be taken as per the health practitioner’s advice.
Contact the emergency services immediately if a patient on this medication shows the following symptoms:
- Breathing issues
- Sudden collapse
- Lost consciousness and cannot regain it on his/her own.
The symptoms of an overdose of this medicine include nausea or vomiting.
Warning and Precautions
Antiflu 75mg can cause severe skin reactions, changes in behavior, and hallucinations. 
Take the following precautions if you are taking Antiflu 75mg:
1. Inform your doctor if you have used oseltamivir for flu in the past or if you have faced any of the following issues before taking this medication:
- Allergic reaction to oseltamivir phosphate or with the other ingredients of this medicine
- Conditions such as HIV that affect your immune system
- Any diseases related to heart, kidney, or lungs
- Pregnancy, breastfeeding, or if you have conceived during the administration of this medicine
- Recent administration of intranasal flu vaccine or planning to getting it soon
- Fructose intolerance
2. Share the entire list of all the prescriptions and over-the-counter medicines, vitamins, supplements, and herbal products that you are taking or plan to take with your doctor.
3. Follow the instructions mentioned below if you have skipped a dose:
- Take the dose as soon as you recollect it
- If you have not taken medicine for more than 2 hours before the next dose, then skip the missed dose and continue with the regular dosing schedule
- Inform your doctor if you have missed several doses.
4. Inform your doctor if you are taking any of the following medicines:
- Medications used in chemotherapy
Possible Side Effects
Some common side effects observed with the use of Antiflu 75mg for influenza are:
- When used for treatment: nausea and vomiting
- When used for prevention: nausea, diarrhea, vomiting, and abdominal pain
The medication may also cause some serious side effects such as:
- Rashes, blisters and hives on skin
- Sores or blisters in the mouth
- Swelling on face, tongue, throat, eyes, and lips
- Breathing issues
- Chest pain
- Shaky movements
- Speech problems
- Hallucinations (start seeing or hearing things that are unreal)
Contact your healthcare provider if you experience any of the abovementioned symptoms and ask for medical advice.
When Should The Drug Not Be Used?
The medicine should not be used if you are allergic to the main ingredient of Antiflu 75mg – oseltamivir phosphate or other ingredients.
- DrugBank. Oseltamivir [Internet] [Updated Feb 12, 2020]. Available at: https://www.drugbank.ca/drugs/DB00198. Accessed on Feb 13, 2020.
- Centers for Disease Control and Prevention. Antiviral drugs for seasonal influenza: Additional links and resources [Internet] [Updated Nov 29, 2018]. Available at: https://www.cdc.gov/flu/professionals/antivirals/links.htm. Accessed on Feb 13, 2020.
- National Center for Biotechnology Information. Oseltamivir [Internet] [Updated 2019 Oct 10]. Available at: https://www.ncbi.nlm.nih.gov/books/NBK539909/. Accessed on Feb 13, 2020.
- U.S. Food and Drug Administration. Highlights of prescribing information. TAMIFLU® (oseltamivir phosphate) capsules, for oral use. TAMIFLU® (oseltamivir phosphate) for oral suspension. [Internet] [Updated Dec, 2012]. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021087s062lbl.pdf. Accessed on Feb 13, 2020.
- MedlinePlus. Oseltamivir [Internet] [Updated Jan 15, 2018]. Available at: https://medlineplus.gov/druginfo/meds/a699040.html. Accessed on Feb 13, 2020.